Smaller wheels are more efficient.
Wheel size is loosely correlated with wheel efficiency. It is true smaller wheels are frequently more efficient, but that is not always the case,
My Rivian 22" OEM wheels are more efficient than the 20" OEM wheels offered by Rivian - by quite a lot actually.
On the Gravity, the 20/21 wheels with Hankook iON tires are definitely the most efficient wheels. However, it is highly possible the efficiency difference between the next larger sizes is not significant using the EPA test cycle.
The 21/22 wheels have All Season tires. The 22/23 wheels have Summer tires. I suspect the Summer tires have lower rolling resistance than the All Season tires, offsetting the better aerodynamic performance of the 21/22 rims. Rolling resistance makes a big difference, and the EPA cycle does not include a lot of high-speed driving, reducing the benefit of aerodynamics in the results.
I agree with you that at 80 MPH, the 21/22 wheels are highly likely to be more efficient than the 22/23 wheels because they appear to be more aerodynamic. However, wheel aerodynamics are part of a system of air flow around the car, and sometimes a rim that looks more aerodynamic is actually not due to the air flow from the vehicle body.
Visually the 22/23 wheel looks like it would have much higher rotational air resistance (resistance as the wheel spins), but there is no way to know for sure unless you do wind tunnel testing on the vehicle and actually measure it. The EPA test results are exactly that. Your eyes are not better than actual test results.
If you want the most efficient setup, get the 20/21 wheels. If you go bigger, the differences appear to be minor with one caveat: EPA does not test at high speed, so likely one wheel is measurably more efficient than the other at 80 mph, and very likely the 21/22 is more efficient, as you assumed. "Very likely" is still a guess, though.