Range is always an interesting topic since everyone's driving style is different and the routes/conditions in which we drive also vary. However, I have detailed my experience thus far below, but this is just one data point so take it with a grain of salt.
My Touring has 20" Aero lite wheels with the aero inserts left installed. After 2,500 miles of driving including an LA-SF and back trip, the lifetime efficiency number is 3.1mi/kwh. Given the 92kwh total battery pack capacity, the math says the real world range at that efficiency is 285miles. Charging only to 80% for daily driving the effective real world range becomes 228miles. When route planning I use 200miles as a comfortable number.
I think the 20" wheels do contribute to an efficiency penalty, but I also have a large grade in my daily commute which drags down the efficiency number as well. I remember seeing a post that said elevation gain has the largest impact on range and I have found that to be true. The grade I drive is ~4miles long, but the car consumes about 13miles of stated range to climb it.
Perhaps a better way to estimate the "idealized" range penalty for the 20" wheels is this: The new published range for the Touring is 425mi with 19" wheels in EPA testing. To hit that number the efficiency value needed is 4.6mi/kwh and even on flat highway driving at 55mph on a 75F day, I haven't been able to achieve that. The best I have seen is 4.0. That would equate to 368mi of range which means the range penalty for the 20" wheels compared to the 19" wheels is ~57 "ideal" miles.